Insulin, Glucagon, and Glucose Exhibit Synchronous, Sustained Oscillations in Fasting Monkeys

In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times greater than for glucose. Insulin cy...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-01, Vol.195 (4274), p.177-179
Main Authors: Goodner, Charles J., Walike, Barbara C., Koerker, Donna J., Ensinck, John W., Brown, Arthur C., Chideckel, Elliott W., Palmer, Jerry, Kalnasy, Lynne
Format: Article
Language:English
Subjects:
Alpha cells
Animals
Atropine - pharmacology
Autocorrelation
Blood Glucose - metabolism
Blood plasma
Eating
Fasting
Glucagon - blood
Haplorhini
Insulin
Insulin - blood
Islets of Langerhans
Islets of Langerhans - physiology
Liver - physiology
Macaca mulatta
Monkeys
Oscillation
Periodicity
Time series
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Summary:In overnight fasted rhesus monkeys, synchronous, regular oscillations occurred in the plasma concentrations of glucose, insulin, and glucagon. The oscillations displayed a period averaging 9 minutes. The amplitudes for insulin and glucagon were ten and five times greater than for glucose. Insulin cycled in and glucagon out of phase with glucose. In baboons, oscillations of glucose and insulin were smaller than in rhesus monkeys, while in man, regular oscillations were not observed.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.401543