The effects of tolbutamide on the myocardium in experimental diabetes

The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs r...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1977-01, Vol.55 (1), p.200-205
Main Authors: Wu, C F, Haider, B, Ahmed, S S, Oldewurtel, H A, Lyons, M M, Regan, T J
Format: Article
Language:English
Subjects:
Animals
Blood Glucose - metabolism
Diabetes Mellitus, Experimental - physiopathology
Disease Models, Animal
Dogs
Heart - drug effects
Heart - physiopathology
Hemodynamics - drug effects
Male
Tolbutamide - blood
Tolbutamide - pharmacology
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Summary:The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in the intact anesthetized state showed that treated diabetic dogs had a significantly higher left ventricular end-diastolic pressure of 12.1+/-1.3 mm Hg associated with normal end-diastolic volume, compared to 6.1+/-0.8 mm Hg in untreated diabetics (P less than 0.01) and 6.3+/-0.5 in normals. Stroke work and ejection fraction were similar to normals. Acute volume expansion revealed a larger rise of left ventricular end-diastolic pressure in treated and untreated diabetics than normals, without a significant stroke volume response in treated diabetics. Enhanced stiffness of myocardium appeared to be related to interstitial accumulation of periodic acid-Schiff staining material, further intensified in treated diabetics by triglyceride accumulation observed on electron microscopy and by chemical analysis. Thus treatment of diabetes with tolbutamide, despite improved glucose tolerance, effected further reduction of left ventricular function and altered morphology of myocardium.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.55.1.200