ANAESTHESIA AND THE RETICULO-ENDOTHELIAL SYSTEM: COMPARISON OF HALOTHANE-NITROUS OXIDE AND NEUROLEPTANALGESIA

The effect of halothane anaesthesia and neuroleptanalgesia (NLA) on the phagocytic activity of the reticulo-endothelial system (RES) was investigated with the aid of the Lipofundin clearance test. The results suggest that halothane in nitrous oxide depresses the phagocytic activity of the RES. NLA d...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1976-12, Vol.48 (12), p.1191-1195
Main Authors: DOENICKE, A., KROPP, W.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia, Inhalation
Droperidol - pharmacology
Etomidate - pharmacology
Fentanyl - pharmacology
Halothane - pharmacology
Humans
Male
Middle Aged
Mononuclear Phagocyte System - drug effects
Neuroleptanalgesia
Nitrous Oxide - pharmacology
Phagocytes - drug effects
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Summary:The effect of halothane anaesthesia and neuroleptanalgesia (NLA) on the phagocytic activity of the reticulo-endothelial system (RES) was investigated with the aid of the Lipofundin clearance test. The results suggest that halothane in nitrous oxide depresses the phagocytic activity of the RES. NLA did not exert a depressant effect on the RES function. As it is essential for the body to be in a defensive condition to cope adequately with infection and cancer metastases, care must be taken to ensure that an anaesthetic procedure does not cause additional impairment of RES function. The results of the investigations suggest that NLA may have advantages in this respect
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/48.12.1191