Effect of protracted intermittent fasting on the activities of enzymes involved in energy metabolism, and on the concentrations of glycogen, protein and DNA in skeletal muscle of obese women

In the quadriceps femoris muscle of obese women the glycogen concentration was significantly lower than in the control group, while protein and DNA values showed no significant differences. After 37 days of intermittent fasting, which consisted of repeated 5-day fasts alternating with 3-day interval...

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Bibliographic Details
Published in:Nutrition and metabolism (Basel) 1976, Vol.20 (5), p.329-337
Main Authors: Vondra, K, Rath, R, Bass, A, Kuzela, L, Slabochova, Z
Format: Article
Language:English
Subjects:
Adult
DNA - metabolism
Energy Metabolism
Fasting
Female
Glycogen - metabolism
Hexokinase - metabolism
human nutrition
Humans
Middle Aged
Muscle Proteins - metabolism
Muscles - enzymology
Muscles - metabolism
nutrition education
Obesity - enzymology
Obesity - metabolism
Oxidoreductases - metabolism
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Summary:In the quadriceps femoris muscle of obese women the glycogen concentration was significantly lower than in the control group, while protein and DNA values showed no significant differences. After 37 days of intermittent fasting, which consisted of repeated 5-day fasts alternating with 3-day intervals on 500 kcal/day with 60 g protein, in a group of 21 obese women a significant decline of the hexokinase activity in skeletal muscle was found. Other enzymes: triosophosphate dehydrogenase, lactate dehydrogenase, glycerol-3-phosphate dehydrogenase, citrate synthase, malate dehydrogenase and hydroxyacyl-CoA dehydrogenase showed no significant changes. There was a significant fall in concentration of DNA and glycogen, but the protein concentration did not change.
ISSN:0029-6678
2571-6506