Does cyclic GMP mediate the slow excitatory synaptic potential in sympathetic ganglia?

THE slow excitatory postsynaptic potential (slow EPSP) of vertebrate sympathetic ganglia is elicited by the muscarinic action of acetylcholine 1,2 . Its electrogenic mechanism appears strikingly different from that of the well-known (fast) EPSP in many respects—most notably that it is generated with...

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Bibliographic Details
Published in:Nature (London) 1978-01, Vol.271 (5642), p.267-268
Main Authors: HASHIGUCHI, TOSHIO, USHIYAMA, NAKAKO S, KOBAYASHI, HARUO, LIBET, BENJAMIN
Format: Article
Language:English
Subjects:
Animals
Cholinergic Fibers - physiology
Cyclic GMP - pharmacology
Electric Conductivity
Ganglia, Autonomic - physiology
Humanities and Social Sciences
In Vitro Techniques
Kinetics
letter
Membrane Potentials - drug effects
multidisciplinary
Rabbits
Science
Science (multidisciplinary)
Synaptic Membranes - physiology
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Summary:THE slow excitatory postsynaptic potential (slow EPSP) of vertebrate sympathetic ganglia is elicited by the muscarinic action of acetylcholine 1,2 . Its electrogenic mechanism appears strikingly different from that of the well-known (fast) EPSP in many respects—most notably that it is generated with no detectable increase in membrane conductance 3 . As this type of transmitter action is probably related to cholinergic processes in the brain 4,5 and possibly in the spinal cord 6 , further study of the slow EPSP in the ganglia as a simpler model of the central cholinergic pathways is of great significance.
ISSN:0028-0836
1476-4687
DOI:10.1038/271267a0