AN INVESTIGATION OF THE CENTRALLY AND PERIPHERALLY MEDIATED CARDIOVASCULAR EFFECTS OF ETOMIDATE IN THE RABBIT

In the decerebrate rabbit etomidate caused dose-related decreases in mean arterial pressure and preganglionic sympathetic nerve activity. There were no significant alterations in heart rate. Etomidate was found to have no effect on the baroreceptor reflex. In pithed animals the effects of etomidate...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1978-02, Vol.50 (2), p.101-108
Main Authors: HUGHES, R.L., MACKENZIE, J.E.
Format: Article
Language:English
Subjects:
Animals
Central Nervous System - physiology
Decerebrate State
Dose-Response Relationship, Drug
Electric Stimulation
Etomidate - pharmacology
Hemodynamics - drug effects
Imidazoles - pharmacology
Male
Rabbits
Sympathetic Nervous System - drug effects
Time Factors
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Summary:In the decerebrate rabbit etomidate caused dose-related decreases in mean arterial pressure and preganglionic sympathetic nerve activity. There were no significant alterations in heart rate. Etomidate was found to have no effect on the baroreceptor reflex. In pithed animals the effects of etomidate were of short duration and of a lesser magnitude than in the decerebrate animal. It was concluded that the additional effects in the decerebrate rabbit were a result of depression of central cardiovascular control. It was found that etomidate was largely without effect on the cardiovascular system at normal anaesthetic doses (0.5−1 mg kg−1). However, larger doses (2–8 mg kg−1) produced marked depression of central cardiovascular control, the myocardium and the peripheral vasculature.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/50.2.101