AN INVESTIGATION OF THE CENTRALLY AND PERIPHERALLY MEDIATED CARDIOVASCULAR EFFECTS OF ETOMIDATE IN THE RABBIT

In the decerebrate rabbit etomidate caused dose-related decreases in mean arterial pressure and preganglionic sympathetic nerve activity. There were no significant alterations in heart rate. Etomidate was found to have no effect on the baroreceptor reflex. In pithed animals the effects of etomidate...

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Published in:British journal of anaesthesia : BJA 1978-02, Vol.50 (2), p.101-108
Main Authors: HUGHES, R.L., MACKENZIE, J.E.
Format: Article
Language:English
Subjects:
Animals
Central Nervous System - physiology
Decerebrate State
Dose-Response Relationship, Drug
Electric Stimulation
Etomidate - pharmacology
Hemodynamics - drug effects
Imidazoles - pharmacology
Male
Rabbits
Sympathetic Nervous System - drug effects
Time Factors
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container_title British journal of anaesthesia : BJA
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MACKENZIE, J.E.
description In the decerebrate rabbit etomidate caused dose-related decreases in mean arterial pressure and preganglionic sympathetic nerve activity. There were no significant alterations in heart rate. Etomidate was found to have no effect on the baroreceptor reflex. In pithed animals the effects of etomidate were of short duration and of a lesser magnitude than in the decerebrate animal. It was concluded that the additional effects in the decerebrate rabbit were a result of depression of central cardiovascular control. It was found that etomidate was largely without effect on the cardiovascular system at normal anaesthetic doses (0.5−1 mg kg−1). However, larger doses (2–8 mg kg−1) produced marked depression of central cardiovascular control, the myocardium and the peripheral vasculature.
doi_str_mv 10.1093/bja/50.2.101
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ispartof British journal of anaesthesia : BJA, 1978-02, Vol.50 (2), p.101-108
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source Oxford University Press:Jisc Collections:Oxford Journal Archive: Access period 2024-2025
subjects Animals
Central Nervous System - physiology
Decerebrate State
Dose-Response Relationship, Drug
Electric Stimulation
Etomidate - pharmacology
Hemodynamics - drug effects
Imidazoles - pharmacology
Male
Rabbits
Sympathetic Nervous System - drug effects
Time Factors
title AN INVESTIGATION OF THE CENTRALLY AND PERIPHERALLY MEDIATED CARDIOVASCULAR EFFECTS OF ETOMIDATE IN THE RABBIT
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