Dihydroergotoxine: Separation and Determination of Four Components by High-Performance Liquid Chromatography

The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-ph...

Full description

Saved in:
Bibliographic Details
Published in:Journal of pharmaceutical sciences 1978-01, Vol.67 (1), p.98-103
Main Authors: Hartmann, V., Rödiger, M., Ableidinger, W., Bethke, H.
Format: Article
Language:English
Subjects:
Antiadrenergic agents-dihydroergotoxine
Antiadrenergic agents—dihydroergotoxine high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations
Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid
Dihydroergotoxine - analysis
Dihydroergotoxine - isolation & purification
Dihydroergotoxine-high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations
four components of dihydroergotoxine in bulk drug and pharmaceutical formulations
high-performance liquid chromatographic analyses of four components in bulk drug and pharmaceutical formulations
High-performance liquid chromatography-analyses
High-performance liquid chromatography—analyses four components of dihydroergotoxine in bulk drug and pharmaceutical formulations
Solutions - analysis
Tablets - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The evaluation of a new high-performance liquid chromatographic method is described. It permits the separation and determination of the four components of dihydroergotoxine (dihydroergocristine, dihydroergocornine, dihydro-α-ergocryptine, and dihydro-β-ergocryp-tine) in a single step. On reversed-phase microparticles, complete baseline separation is possible with different mobile phases containing about 10–2M base. The analysis of dihydroergotoxine mesylate drug substance or its dosage forms can be carried out in about 15min. No reference substance is required for the determination of the proportions of the components. This method is simple and exhibits high accuracy, reproducibility, and selectivity. It permits the analytical control of dosage forms containing dihydroergotoxine mesylate to ensure that they comply with the specifications for the drug substance used in clinical and pharmacological studies.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600670125