Fluidity in the Membranes of Adult and Neonatal Human Erythrocytes

Several antigens and receptors are mobile in the plane of the membrane of the intact neonatal human erythrocyte but not in the membrane of the normal adult cell. In this report, measurements of the fluorescence polarization of perylene dissolved in isolated erythrocyte membranes are reported, which...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-02, Vol.195 (4277), p.486-487
Main Authors: Kehry, M., Yguerabide, J., Singer, S. J.
Format: Article
Language:English
Subjects:
Adult
Adults
Aging
Cell membranes
Erythrocyte membrane
Erythrocyte Membrane - physiology
Erythrocytes
Erythrocytes - physiology
Fluorescence
Humans
Infant, Newborn
Lipids
Membrane Lipids - physiology
P branes
Receptors
Spectrometry, Fluorescence
String theory
Viscosity
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Summary:Several antigens and receptors are mobile in the plane of the membrane of the intact neonatal human erythrocyte but not in the membrane of the normal adult cell. In this report, measurements of the fluorescence polarization of perylene dissolved in isolated erythrocyte membranes are reported, which are indistinguishable for the two kinds of cells. This result indicates that the viscosities of the membrane interiors of the two cells are the same. The observed mobility differences, therefore, cannot be attributed to different lipid viscosities in the two membranes.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.835005