Hallucinogenic N-Methylated Indolealkylamines in the Cerebrospinal Fluid of Psychiatric and Control Populations

The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, thou...

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Bibliographic Details
Published in:British journal of psychiatry 1978-02, Vol.132 (2), p.139-144
Main Authors: Corbett, Lionel, Christian, Samuel T., Morin, Richard D., Benington, Frederick, Smythies, John R.
Format: Article
Language:English
Subjects:
Affective Symptoms - cerebrospinal fluid
Bufotenin - analogs & derivatives
Bufotenin - cerebrospinal fluid
Chromatography, Gas
Humans
N,N-Dimethyltryptamine - cerebrospinal fluid
Schizophrenia - cerebrospinal fluid
Serotonin - analogs & derivatives
Tryptamines - cerebrospinal fluid
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Summary:The incidence and quantities of dimethyltryptamine and O-methyl-bufotenine were studied in the cerebrospinal fluid of patients suffering acute schizophrenic illnesses and in surgical and neurological control groups. Some schizophrenic patients have higher levels of both amines than do controls, though the differences in distribution did not reach statistical significance in the sample studied. The gas-chromatographic technique used is sensitive at the low picogram level.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.132.2.139