Quick Estimation of Kinetic Parameters for a Compartment with Exponential Absorption Rate and First‐Order Elimination Rate

• Published in: Journal of pharmaceutical sciences 1977-01, Vol.66 (1), p.127-129
• Main Author: Thron, C.D.
• Format: Article
• Language: English
• Subjects: Absorption; Kinetic parameters-compartment with exponential absorption rate and first-order elimination rate; Kinetic parameters—compartment with exponential absorption rate and first‐order elimination rate, two methods for quick estimation; Kinetics; Methods; Models, Biological; Pharmaceutical Preparations - metabolism; Pharmacokinetics-compartment with exponential absorption rate and first-order elimination rate; Pharmacokinetics—compartment with exponential absorption rate and first‐order elimination rate, two methods for quick estimation of kinetic parameters; two methods for quick estimation; two methods for quick estimation of kinetic parameters
• ISSN: 0022-3549; 1520-6017
• DOI: 10.1002/jps.2600660137

Two methods are presented for the quick estimation of kinetic parameters for a compartment with an exponential absorption rate and a first‐order elimination rate. The first method is by direct computation from the observed levels of substance in the compartment at times t, 2t and 3t, where t is arbitrary. The second method uses a numerical table to estimate the parameters from the observed peak level, the time of the peak level (or the time when the level rises to half of the peak level) and the time when the level has declined to half of its peak value. Some approximation equations also are given.