Dose dependency of the post-insult protective effect of pentobarbital in the canine experimental stroke model

In a canine stroke model, dose dependent protection by postocclusion pentobarbital was suggested from 10--40 mg/kg. In 28 dogs investigated (10 from a previous study) a distinct, significant reduction in right cerebral hemisphere infarction occurred in animals given 15--20 mg/kg pentobarbital intram...

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Bibliographic Details
Published in:Stroke (1970) 1978-01, Vol.9 (1), p.10-12
Main Authors: Corkill, G, Sivalingam, S, Reitan, J A, Gilroy, B A, Helphrey, M G
Format: Article
Language:English
Subjects:
Animals
Cerebrovascular Disorders - prevention & control
Disease Models, Animal
Dogs
Dose-Response Relationship, Drug
Intracranial Embolism and Thrombosis - prevention & control
Pentobarbital - administration & dosage
Pentobarbital - pharmacology
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Summary:In a canine stroke model, dose dependent protection by postocclusion pentobarbital was suggested from 10--40 mg/kg. In 28 dogs investigated (10 from a previous study) a distinct, significant reduction in right cerebral hemisphere infarction occurred in animals given 15--20 mg/kg pentobarbital intramuscularly 1 hour postocclusion. Increased dosages did not alter statistically the infarct size and 2 dogs at the 50 mg/kg and 80 mg/kg levels died of barbiturate-induced respiratory failure.
ISSN:0039-2499
1524-4628
DOI:10.1161/01.str.9.1.10