Immunohistochemical localization of neurotensin in endocrine cells of the gut

Endocrine cells displaying neurotensin immunoreactivity are found scattered in the jejuno-ileum of all mammals studied, including man. They are rather scarce in rat, guinea pig, rabbit and pig and fairly numerous in cat, dog and man. In most mammals the neurotensin cells predominate on the villi. On...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 1977-03, Vol.178 (3), p.313-321
Main Authors: Sundler, F, Håkanson, R, Hammer, R A, Alumets, J, Carraway, R, Leeman, S E, Zimmerman, E A
Format: Article
Language:English
Subjects:
Age Factors
Animals
Chickens
Digestive System - embryology
Digestive System - growth & development
Female
Fluorescent Antibody Technique
Gastric Mucosa - analysis
Gastrointestinal Hormones - analysis
Histocytochemistry
Humans
Intestinal Mucosa - analysis
Peptides - analysis
Pregnancy
Rats
Stomach, Avian
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Endocrine cells displaying neurotensin immunoreactivity are found scattered in the jejuno-ileum of all mammals studied, including man. They are rather scarce in rat, guinea pig, rabbit and pig and fairly numerous in cat, dog and man. In most mammals the neurotensin cells predominate on the villi. Only in the dog are they more numerous in the crypts. In the chicken, neurotensin cells occur all along the intestinal tract. They are particularly numerous in the zone that joins the gizzard with the duodenum. The ontogeny of the neurotensin cells in the gut was studied in rats and chickens. In the rat, the cells are first observed in the jejuno-ileum immediately before birth. The adult frequency is reached 4-5 days later. In the chicken, neurotensin cells first appear in the colon in the 18 day old embryo and in the small intestine two days later (i.e. one or two days before hatching). A few days after hatching, the gut has achieved the adult number of neurotensin cells per unit area.
ISSN:0302-766X
1432-0878
DOI:10.1007/bf00218696