Screening hallucinogenic drugs II. Systematic study of two behavioral tests

The effects of hallucinogenic and nonhallucinogenic drugs were studied on two behavioral tests: (1) discriminated Sidman avoidance, using modified Bovet-Gatti profiles, which have been proposed as specific in detecting hallucinogenic activity and (2) a drug discrimination experiment. By the first me...

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Bibliographic Details
Published in:Psychopharmacology 1978-01, Vol.56 (1), p.87-92
Main Author: Calil, H M
Format: Article
Language:English
Subjects:
Animals
Avoidance Learning - drug effects
Behavior, Animal - drug effects
Conditioning, Operant - drug effects
Discrimination (Psychology) - drug effects
Discrimination Learning - drug effects
Dronabinol - pharmacology
Drug Evaluation, Preclinical - methods
Generalization (Psychology) - drug effects
Hallucinogens - pharmacology
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Rats
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Summary:The effects of hallucinogenic and nonhallucinogenic drugs were studied on two behavioral tests: (1) discriminated Sidman avoidance, using modified Bovet-Gatti profiles, which have been proposed as specific in detecting hallucinogenic activity and (2) a drug discrimination experiment. By the first method, the "hallucinogenic profile" was obtained with both hallucinogenic and nonhallucinogenic drugs and, at least as used here, was not a suitable screening method. In the drug discrimination experiment, data from the present study along with other available evidence suggest the potential value of this method for drug screening procedures.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00571414