Effects of systemic administration of 6-hydroxydopamine on the circumventricular organs in nonhuman primates. I. Area postrema

6-Hydroxydopamine (6-OH-DA) has been shown to produce degenerative changes in noradrenergic nerve terminals and preterminals in the CNS following intracisternal, intraventricular or direct injection into the brain parenchyma. Systemic injection of 6-OH-DA is known to result in degenerative changes i...

Full description

Saved in:
Bibliographic Details
Published in:Cell and tissue research 1978-02, Vol.187 (1), p.115-127
Main Authors: Brizzee, K R, Palazzo, M C, Klara, P M, Hofer, H
Format: Article
Language:English
Subjects:
Animals
Astrocytes - ultrastructure
Axons - ultrastructure
Brain - drug effects
Cerebral Ventricles
Female
Glycogen - analysis
Haplorhini
Hydroxydopamines - pharmacology
Lysosomes - ultrastructure
Macaca fascicularis
Mast Cells - ultrastructure
Microscopy, Electron
Nerve Degeneration
Nerve Endings - drug effects
Neurons - ultrastructure
Norepinephrine
Saimiri
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:6-Hydroxydopamine (6-OH-DA) has been shown to produce degenerative changes in noradrenergic nerve terminals and preterminals in the CNS following intracisternal, intraventricular or direct injection into the brain parenchyma. Systemic injection of 6-OH-DA is known to result in degenerative changes in noradrenergic terminals in the peripheral nervous system. However, only a few studies have been carried out on the effects of systemic injections of 6-OH-DA on noradrenergic terminals in the CNS. In the present study cynomolgus and squirrel monkeys were injected intravenously on two successive days with total doses of 350 mg/kg and 150 mg/kg of 6-OH-DA, respectively, and sacrificed at 2 and 24 h following the second injection. Degenerative changes in the area postrema (AP) neurons in all injected animals were characterized by a generalized increase in electron density of cytoplasmic elements in axonal terminals and preterminals. Multilamellar bodies, clusters of clear and dense core vesicles, increased numbers of secondary lysosomes, and an increase in the number of glycogen increased markedly in injected animals, but no other glial alterations were observed. The number of mast cells in the AP was greater in injected than in noninjected animals, both in the perivascular spaces (PVS) and in parenchymal locations. Cell processes in the PVS were occasionally observed to contain electron dense bodies, and degenerative changes were seen in supraependymal processes in some injected animals.
ISSN:0302-766X
1432-0878
DOI:10.1007/BF00220623