Verapamil in the management of supraventricular tachyarrhythmias occurring after a recent myocardial infarction

In 16 patients, a sustained supraventricular tachyarrhythmia occurring less than 72 hours after the first symptom of an acute myocardial infarction was treated with titrated doses of verapamil. The drug was given intravenously in 1 mg increments every minute under continuous monitoring of electrocar...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1978-04, Vol.57 (4), p.751-755
Main Author: Hagemeijer, F
Format: Article
Language:English
Subjects:
Blood Pressure - drug effects
Electrocardiography
Female
Heart Rate - drug effects
Humans
Male
Middle Aged
Myocardial Infarction - complications
Tachycardia, Paroxysmal - drug therapy
Tachycardia, Paroxysmal - etiology
Verapamil - therapeutic use
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Summary:In 16 patients, a sustained supraventricular tachyarrhythmia occurring less than 72 hours after the first symptom of an acute myocardial infarction was treated with titrated doses of verapamil. The drug was given intravenously in 1 mg increments every minute under continuous monitoring of electrocardiogram and blood pressure. Endpoints for the administration of verapamil were the following: reversion to sinus rhythm; a ventricular rate slower than 100/min; hypotension; a pulmonary capillary wedge pressure rising above 15 mm Hg; signs of intolerance; a maximum dose of 20 mg. Reversion to sinus rhythm was observed in 7/8 patients in atrial flutter and in 1/8 patients in atrial fibrillation; in all the ventricular rate could be slowed below 100/min without untoward effects.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.57.4.751