Influenza B-Associated Reye's Syndrome: Incidence in Michigan and Potential for Prevention

Prospective surveillance for Reye's syndrome in Michigan revealed the occurrence of 46 cases between December 15, 1973 and June I, 1974. In an attempt to determine the incidence of influenza B-associated Reye's syndrome, a randomized point-prevalence survey of 1,041 schoolchildren was done...

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Bibliographic Details
Published in:The Journal of infectious diseases 1977-03, Vol.135 (3), p.398-407
Main Authors: Corey, Lawrence, Rubin, Robert J., Thompson, Theodore R., Noble, Gary R., Cassidy, Edward, Hattwick, Michael A. W., Gregg, Michael B., Eddins, Donald
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age distribution
Antibodies
Antibodies, Viral - analysis
Child
Child, Preschool
Children
Disease outbreaks
Disease Outbreaks - epidemiology
Epidemiology
Female
Hemagglutination Inhibition Tests
Humans
Influenza, Human - epidemiology
Major Articles
Male
Michigan
Orthomyxoviridae
Orthomyxoviridae - immunology
Reye syndrome
Reye Syndrome - epidemiology
Reye Syndrome - etiology
Reye Syndrome - prevention & control
Rural Population
Student absenteeism
Surveillance
Vaccination
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Summary:Prospective surveillance for Reye's syndrome in Michigan revealed the occurrence of 46 cases between December 15, 1973 and June I, 1974. In an attempt to determine the incidence of influenza B-associated Reye's syndrome, a randomized point-prevalence survey of 1,041 schoolchildren was done in a county in Michigan where there had been simultaneous outbreaks of influenza Band Reye's syndrome. Of the children tested, 20% had titers of hemagglutination-inhibiting antibody to influenza virus B/Hong Kong/5/72 of ⩾1:20. Based upon this countywide survey, the incidence of Reye's syndrome following influenza B was estimated as between 30.8 and 57.8 cases of Reye's syndrome per 100,000 cases of influenza B. A detailed epidemiologic investigation of the patients who developed Reye's syndrome indicated that the syndrome occurred four times more frequently in children living in rural areas than in children in the urban areas of the state. These studies indicate that, in addition to antecedent viral infections such as influenza B, factor(s) that are most likely extrinsic or environmental also playa role in the pathogenesis of Reye's syndrome.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/135.3.398