Electron-Capture GLC Determination of Nanogram to Picogram Amounts of Isosorbide Dinitrate

A GLC method for the determination of plasma isosorbide dinitrate using electron-capture detection is described. The organic nitrates are especially suited for electron-capture detection if the detector temperature is optimized for maximum sensitivity, e.g., 175°. Proper maintenance of the detector...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1977-03, Vol.66 (3), p.384-386
Main Authors: Malbica, J.O., Monson, K., Neilson, K., Sprissler, R.
Format: Article
Language:English
Subjects:
Adult
Chromatography, Gas
coronary-isosorbide dinitrate
electron capture-analysis
electron-capture GLC analysis
Female
GLC
GLC, electron capture—analysis, isosorbide dinitrate, human plasma
human plasma
Humans
isosorbide dinitrate
Isosorbide Dinitrate - administration & dosage
Isosorbide Dinitrate - blood
Isosorbide dinitrate-electron-capture GLC analysis
Isosorbide dinitrate—electron-capture GLC analysis, human plasma
Male
Mastication
Methods
Tablets
Time Factors
Vasodilators
Vasodilators, coronary—isosorbide dinitrate, electron-capture GLC analysis, human plasma
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Summary:A GLC method for the determination of plasma isosorbide dinitrate using electron-capture detection is described. The organic nitrates are especially suited for electron-capture detection if the detector temperature is optimized for maximum sensitivity, e.g., 175°. Proper maintenance of the detector and column assures reproducible data in the low nanogram range. The extraction procedure described is simple, efficient, and expedient for processing large numbers of samples. The method was used to study plasma levels in four human volunteers after a single dose of a 5-mg chewable isosorbide dinitrate tablet. Concentration levels of isosorbide dinitrate as low as 0.5ng/ml of plasma can be measured by this procedure.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600660318