Loading…

Induction of sister chromatid exchanges by transformation with simian virus 40

The frequency of sister chromatid exchange (SCE) has been followed sequentially after the addition of SV40 to human diploid fibroblast cultures. The SCE frequency was nearly the same in uninfected controls and in infected cultures before they became tumor antigen positive. When cells exhibited tumor...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1978-04, Vol.38 (4), p.960-964
Main Authors: Nichols, W W, Bradt, C I, Toji, L H, Godley, M, Segawa, M
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 964
container_issue 4
container_start_page 960
container_title Cancer research (Chicago, Ill.)
container_volume 38
creator Nichols, W W
Bradt, C I
Toji, L H
Godley, M
Segawa, M
description The frequency of sister chromatid exchange (SCE) has been followed sequentially after the addition of SV40 to human diploid fibroblast cultures. The SCE frequency was nearly the same in uninfected controls and in infected cultures before they became tumor antigen positive. When cells exhibited tumor antigen, the SCE frequency increased over a wide range, and changes in chromosome number and structure were observed simultaneously. Cells with induced chromosome abnormalities without increased SCE's and the reverse present the possibility that the two phenomena have different viral mechanisms. This increase in SCE can be added to the previously demonstrated change in chromosome number and increase in chromosome breakage and rearrangement as indicators of genetic damage associated with viral transformation.
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_83851089</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>83851089</sourcerecordid><originalsourceid>FETCH-LOGICAL-h237t-25cd9db583cb2e8478b1e33e219a36417ebf94d52eaac544be7a508ea64ddfe33</originalsourceid><addsrcrecordid>eNotj8lOwzAYhH1gK4U34OATt0iOl8Y5ooqlUgUXOEde_hCjxC62A_TtcdWeRqP5ZqQ5QwtCiKwEb-gVuk7pq1hRE3GJLigRTLAFet14O5vsgsehx8mlDBGbIYZJZWcx_JlB-U9IWO9xjsqnPsRDVPhfl4fSmJzy-MfFOWFObtB5r8YEtyddoo-nx_f1S7V9e96sH7bVQFmTKyqMba0WkhlNQfJG6hoYA1q3iq143YDuW24FBaWM4FxDowSRoFbc2r6QS3R_3N3F8D1Dyt3kkoFxVB7CnDrJZDkq2wLencBZT2C7XXSTivvu-J_9A1kyVtQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>83851089</pqid></control><display><type>article</type><title>Induction of sister chromatid exchanges by transformation with simian virus 40</title><source>EZB Electronic Journals Library</source><creator>Nichols, W W ; Bradt, C I ; Toji, L H ; Godley, M ; Segawa, M</creator><creatorcontrib>Nichols, W W ; Bradt, C I ; Toji, L H ; Godley, M ; Segawa, M</creatorcontrib><description>The frequency of sister chromatid exchange (SCE) has been followed sequentially after the addition of SV40 to human diploid fibroblast cultures. The SCE frequency was nearly the same in uninfected controls and in infected cultures before they became tumor antigen positive. When cells exhibited tumor antigen, the SCE frequency increased over a wide range, and changes in chromosome number and structure were observed simultaneously. Cells with induced chromosome abnormalities without increased SCE's and the reverse present the possibility that the two phenomena have different viral mechanisms. This increase in SCE can be added to the previously demonstrated change in chromosome number and increase in chromosome breakage and rearrangement as indicators of genetic damage associated with viral transformation.</description><identifier>ISSN: 0008-5472</identifier><identifier>PMID: 205353</identifier><language>eng</language><publisher>United States</publisher><subject>Antigens, Viral ; Cell Transformation, Neoplastic ; Cells, Cultured ; Crossing Over, Genetic ; Humans ; Simian virus 40 - immunology</subject><ispartof>Cancer research (Chicago, Ill.), 1978-04, Vol.38 (4), p.960-964</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/205353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nichols, W W</creatorcontrib><creatorcontrib>Bradt, C I</creatorcontrib><creatorcontrib>Toji, L H</creatorcontrib><creatorcontrib>Godley, M</creatorcontrib><creatorcontrib>Segawa, M</creatorcontrib><title>Induction of sister chromatid exchanges by transformation with simian virus 40</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>The frequency of sister chromatid exchange (SCE) has been followed sequentially after the addition of SV40 to human diploid fibroblast cultures. The SCE frequency was nearly the same in uninfected controls and in infected cultures before they became tumor antigen positive. When cells exhibited tumor antigen, the SCE frequency increased over a wide range, and changes in chromosome number and structure were observed simultaneously. Cells with induced chromosome abnormalities without increased SCE's and the reverse present the possibility that the two phenomena have different viral mechanisms. This increase in SCE can be added to the previously demonstrated change in chromosome number and increase in chromosome breakage and rearrangement as indicators of genetic damage associated with viral transformation.</description><subject>Antigens, Viral</subject><subject>Cell Transformation, Neoplastic</subject><subject>Cells, Cultured</subject><subject>Crossing Over, Genetic</subject><subject>Humans</subject><subject>Simian virus 40 - immunology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><recordid>eNotj8lOwzAYhH1gK4U34OATt0iOl8Y5ooqlUgUXOEde_hCjxC62A_TtcdWeRqP5ZqQ5QwtCiKwEb-gVuk7pq1hRE3GJLigRTLAFet14O5vsgsehx8mlDBGbIYZJZWcx_JlB-U9IWO9xjsqnPsRDVPhfl4fSmJzy-MfFOWFObtB5r8YEtyddoo-nx_f1S7V9e96sH7bVQFmTKyqMba0WkhlNQfJG6hoYA1q3iq143YDuW24FBaWM4FxDowSRoFbc2r6QS3R_3N3F8D1Dyt3kkoFxVB7CnDrJZDkq2wLencBZT2C7XXSTivvu-J_9A1kyVtQ</recordid><startdate>197804</startdate><enddate>197804</enddate><creator>Nichols, W W</creator><creator>Bradt, C I</creator><creator>Toji, L H</creator><creator>Godley, M</creator><creator>Segawa, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197804</creationdate><title>Induction of sister chromatid exchanges by transformation with simian virus 40</title><author>Nichols, W W ; Bradt, C I ; Toji, L H ; Godley, M ; Segawa, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h237t-25cd9db583cb2e8478b1e33e219a36417ebf94d52eaac544be7a508ea64ddfe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Antigens, Viral</topic><topic>Cell Transformation, Neoplastic</topic><topic>Cells, Cultured</topic><topic>Crossing Over, Genetic</topic><topic>Humans</topic><topic>Simian virus 40 - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nichols, W W</creatorcontrib><creatorcontrib>Bradt, C I</creatorcontrib><creatorcontrib>Toji, L H</creatorcontrib><creatorcontrib>Godley, M</creatorcontrib><creatorcontrib>Segawa, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nichols, W W</au><au>Bradt, C I</au><au>Toji, L H</au><au>Godley, M</au><au>Segawa, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of sister chromatid exchanges by transformation with simian virus 40</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1978-04</date><risdate>1978</risdate><volume>38</volume><issue>4</issue><spage>960</spage><epage>964</epage><pages>960-964</pages><issn>0008-5472</issn><abstract>The frequency of sister chromatid exchange (SCE) has been followed sequentially after the addition of SV40 to human diploid fibroblast cultures. The SCE frequency was nearly the same in uninfected controls and in infected cultures before they became tumor antigen positive. When cells exhibited tumor antigen, the SCE frequency increased over a wide range, and changes in chromosome number and structure were observed simultaneously. Cells with induced chromosome abnormalities without increased SCE's and the reverse present the possibility that the two phenomena have different viral mechanisms. This increase in SCE can be added to the previously demonstrated change in chromosome number and increase in chromosome breakage and rearrangement as indicators of genetic damage associated with viral transformation.</abstract><cop>United States</cop><pmid>205353</pmid><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0008-5472
ispartof Cancer research (Chicago, Ill.), 1978-04, Vol.38 (4), p.960-964
issn 0008-5472
language eng
recordid cdi_proquest_miscellaneous_83851089
source EZB Electronic Journals Library
subjects Antigens, Viral
Cell Transformation, Neoplastic
Cells, Cultured
Crossing Over, Genetic
Humans
Simian virus 40 - immunology
title Induction of sister chromatid exchanges by transformation with simian virus 40
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A06%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Induction%20of%20sister%20chromatid%20exchanges%20by%20transformation%20with%20simian%20virus%2040&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=Nichols,%20W%20W&rft.date=1978-04&rft.volume=38&rft.issue=4&rft.spage=960&rft.epage=964&rft.pages=960-964&rft.issn=0008-5472&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E83851089%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-h237t-25cd9db583cb2e8478b1e33e219a36417ebf94d52eaac544be7a508ea64ddfe33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=83851089&rft_id=info:pmid/205353&rfr_iscdi=true