Oral fluorouracil therapy of hepatoma

Oral fluorouracil was administered weekly to 12 consecutive patients with unresectable hepatoma. Six patients showed an objective response with a significant increase in survival duration compared to nonresponders and to untreated patients. The clinical features of these cases are discussed, along w...

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Bibliographic Details
Published in:Cancer 1977-05, Vol.39 (5), p.1930-1935
Main Authors: Kennedy, Peter S., Lehane, Daniel E., Smith, Frank E., Lane, Montague
Format: Article
Language:English
Subjects:
Administration, Oral
Carcinoma, Hepatocellular - blood
Carcinoma, Hepatocellular - drug therapy
Drug Administration Schedule
Female
Fluorouracil - administration & dosage
Fluorouracil - blood
Fluorouracil - therapeutic use
Humans
Liver Neoplasms - blood
Liver Neoplasms - drug therapy
Male
Middle Aged
Remission, Spontaneous
Time Factors
Citations: Items that this one cites
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Summary:Oral fluorouracil was administered weekly to 12 consecutive patients with unresectable hepatoma. Six patients showed an objective response with a significant increase in survival duration compared to nonresponders and to untreated patients. The clinical features of these cases are discussed, along with details of therapy, and possible reasons for the encouraging results noted with this treatment regimen.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197705)39:5<1930::AID-CNCR2820390503>3.0.CO;2-7