Immunoglobulins and Viral Antibodies in Psychiatric Patients

The serum and CSF of 66 patients with functional psychoses were tested for immunoglobulins and antibodies to measles, HSV-1, CMV, and rubella viruses. Ten surgical and 80 neurological patients were controls. There were no significant findings in the serum, consistent with most previous studies. In t...

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Bibliographic Details
Published in:British journal of psychiatry 1978-04, Vol.132 (4), p.342-348
Main Authors: Torrey, E. Fuller, Peterson, Michael R., Brannon, William L., Carpenter, William T., Post, Robert M., Van Kammen, Daniel P.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antibodies, Viral - analysis
Antibodies, Viral - cerebrospinal fluid
Female
Humans
Immunoglobulin G - cerebrospinal fluid
Immunoglobulins - analysis
Immunoglobulins - cerebrospinal fluid
Male
Measles virus - immunology
Middle Aged
Psychotic Disorders - blood
Psychotic Disorders - cerebrospinal fluid
Psychotic Disorders - immunology
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Summary:The serum and CSF of 66 patients with functional psychoses were tested for immunoglobulins and antibodies to measles, HSV-1, CMV, and rubella viruses. Ten surgical and 80 neurological patients were controls. There were no significant findings in the serum, consistent with most previous studies. In the CSF 6 of 17 multiple admission schizophrenic patients had definite elevations of IgG or measles antibody and differed significantly from the surgical controls. Immunologically this group resembled the seriously ill neurological patients. No previous study has been made of immunoglobulins or viral antibodies in the CSF of psychiatric patients. It is concluded that further work is warranted in a search for biological subgroups of schizophrenia.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.132.4.342