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Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae

Careful pathological examination of lumbar spines removed at autopsy has shown that degenerative changes are present in the intervertebral discs of all subjects by middle age. The degenerative changes are more marked and occur at an earlier age when evidence of vertical or posterior disc prolapse is...

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Published in:	Rheumatology and rehabilitation 1977-02, Vol.16 (1), p.13-21
Main Authors:	Vernon-Roberts, B, Pirie, C J
Format:	Article
Language:	English
Subjects:	Adolescent Adult Age Factors Aged Back - innervation Bone Diseases - pathology Child Female Humans Infant, Newborn Intervertebral Disc - diagnostic imaging Intervertebral Disc - pathology Intervertebral Disc Displacement - pathology Joint Diseases - pathology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Lumbosacral Region - diagnostic imaging Lumbosacral Region - innervation Male Middle Aged Radiography Spinal Diseases - pathology Spinal Osteophytosis - pathology
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creator	Vernon-Roberts, B Pirie, C J
description	Careful pathological examination of lumbar spines removed at autopsy has shown that degenerative changes are present in the intervertebral discs of all subjects by middle age. The degenerative changes are more marked and occur at an earlier age when evidence of vertical or posterior disc prolapse is also present. Degenerative changes in the discs are always accompanied by osteophyte formation on the margins of the vertebral bodies and remodelling changes in the apophyseal joints. There is a direct relationship between the degree of disc degeneration, marginal osteophyte formation on vertebral bodies, and apophyseal joint changes, which suggests that disc degeneration is the primary event leading to the clinical condition of 'degenerative spondylosis'.
doi_str_mv	10.1093/rheumatology/16.1.13
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The degenerative changes are more marked and occur at an earlier age when evidence of vertical or posterior disc prolapse is also present. Degenerative changes in the discs are always accompanied by osteophyte formation on the margins of the vertebral bodies and remodelling changes in the apophyseal joints. 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There is a direct relationship between the degree of disc degeneration, marginal osteophyte formation on vertebral bodies, and apophyseal joint changes, which suggests that disc degeneration is the primary event leading to the clinical condition of 'degenerative spondylosis'.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Back - innervation</subject><subject>Bone Diseases - pathology</subject><subject>Child</subject><subject>Female</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Intervertebral Disc - diagnostic imaging</subject><subject>Intervertebral Disc - pathology</subject><subject>Intervertebral Disc Displacement - pathology</subject><subject>Joint Diseases - pathology</subject><subject>Lumbar Vertebrae - diagnostic imaging</subject><subject>Lumbar Vertebrae - pathology</subject><subject>Lumbosacral Region - diagnostic imaging</subject><subject>Lumbosacral Region - innervation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Radiography</subject><subject>Spinal Diseases - pathology</subject><subject>Spinal Osteophytosis - pathology</subject><issn>0300-3396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1977</creationdate><recordtype>article</recordtype><recordid>eNotUMtOwzAQ9IFXKfxBDz5xS7qukzg-okIBqRIXEMfIsTdtkPPAdir17zG0p9E8NDtaQhYMUgaSL90ep06FwQ6745IVKUsZvyAz4AAJ57K4IbfefwNkOQN-Ta7KTPAVzMjXE-6wR6dCe0Cq96rfoadtT8MeIwR0B3QBa6csNa3Xng7Nv2enrlaO-rHtkare_Ilt5PgzoVV4Ry4bZT3en3FOPjfPH-vXZPv-8rZ-3CY6rgpJpnnOS54bAQVoaaARWpgCoZG5kapWqFaoNZQ1y3LeCMHKXNYiQ4OFbqI0Jw-n3tEN8bIPVRdXorWqx2HyVclLkYEUMbg4B6e6Q1ONru2UO1anR_Bf4pJiDg</recordid><startdate>197702</startdate><enddate>197702</enddate><creator>Vernon-Roberts, B</creator><creator>Pirie, C J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>197702</creationdate><title>Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae</title><author>Vernon-Roberts, B ; Pirie, C J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-4c353835d7060c9d0f7c7d6e0f95d9abaea2ecc08b1453f771859b74ede6cf453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1977</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Back - innervation</topic><topic>Bone Diseases - pathology</topic><topic>Child</topic><topic>Female</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Intervertebral Disc - diagnostic imaging</topic><topic>Intervertebral Disc - pathology</topic><topic>Intervertebral Disc Displacement - pathology</topic><topic>Joint Diseases - pathology</topic><topic>Lumbar Vertebrae - diagnostic imaging</topic><topic>Lumbar Vertebrae - pathology</topic><topic>Lumbosacral Region - diagnostic imaging</topic><topic>Lumbosacral Region - innervation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Radiography</topic><topic>Spinal Diseases - pathology</topic><topic>Spinal Osteophytosis - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vernon-Roberts, B</creatorcontrib><creatorcontrib>Pirie, C J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology and rehabilitation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vernon-Roberts, B</au><au>Pirie, C J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae</atitle><jtitle>Rheumatology and rehabilitation</jtitle><addtitle>Rheumatol Rehabil</addtitle><date>1977-02</date><risdate>1977</risdate><volume>16</volume><issue>1</issue><spage>13</spage><epage>21</epage><pages>13-21</pages><issn>0300-3396</issn><abstract>Careful pathological examination of lumbar spines removed at autopsy has shown that degenerative changes are present in the intervertebral discs of all subjects by middle age. The degenerative changes are more marked and occur at an earlier age when evidence of vertical or posterior disc prolapse is also present. Degenerative changes in the discs are always accompanied by osteophyte formation on the margins of the vertebral bodies and remodelling changes in the apophyseal joints. There is a direct relationship between the degree of disc degeneration, marginal osteophyte formation on vertebral bodies, and apophyseal joint changes, which suggests that disc degeneration is the primary event leading to the clinical condition of 'degenerative spondylosis'.</abstract><cop>England</cop><pmid>847320</pmid><doi>10.1093/rheumatology/16.1.13</doi><tpages>9</tpages></addata></record>
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source	Oxford University Press Archive
subjects	Adolescent Adult Age Factors Aged Back - innervation Bone Diseases - pathology Child Female Humans Infant, Newborn Intervertebral Disc - diagnostic imaging Intervertebral Disc - pathology Intervertebral Disc Displacement - pathology Joint Diseases - pathology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Lumbosacral Region - diagnostic imaging Lumbosacral Region - innervation Male Middle Aged Radiography Spinal Diseases - pathology Spinal Osteophytosis - pathology
title	Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae
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