Mouse Chromosome Translocations: Visualization and Analysis by Electron Microscopy of the Synaptonemal Complex

Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-05, Vol.196 (4292), p.892-894
Main Authors: Moses, Montrose J., Russell, Liane B., Cacheiro, N. L. A.
Format: Article
Language:English
Subjects:
Animals
Autosomes
Chromosome Aberrations
Chromosome translocation
Chromosomes
Chromosomes - ultrastructure
Electron microscopy
Electrons
Embryos
Genetic loci
Heterozygote
Male
Meiosis
Mice
Microscopy, Electron
Pachytene stage
Reciprocal translocation
Sex Chromosomes - ultrastructure
Spermatocytes - ultrastructure
Synaptonemal complex
Translocation, Genetic
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Description
Summary:Pachytene chromosomes of mice heterozygous for known translocations are clearly depicted by configurations of the synaptonemal complexes in spread (whole mount) preparations. In one autosomal and two X-autosome translocations analyzed, breakpoints are identifiable; localization by measurement agrees with mitotic data and shows the translocations to be reciprocal. Synapsis with the Y is inhibited in one translocation in which the breakpoint is in the pairing region of the X.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.870966