ABSENCE OF “RECURARIZATION” IN PATIENTS WITH DEMONSTRATED PROLONGED NEUROMUSCULAR BLOCK

The possibility of “recurarization” after antagonism of the competitive neuromuscular block with anticholinesterases was studied. Observations were made on the time-course of the block in five patients at risk from recurarization because of multiple organ failure and who demonstrated unusually prolo...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1977-05, Vol.49 (5), p.485-489
Main Authors: LEE, CHINGMUH, MOK, MARTIN. S., BARNES, ANGELINE, KATZ, RONALD. L.
Format: Article
Language:English
Subjects:
Adult
Cholinesterase Inhibitors - pharmacology
Edrophonium - pharmacology
Female
Humans
Male
Middle Aged
Neostigmine - pharmacology
Neuromuscular Blocking Agents - antagonists & inhibitors
Neuromuscular Junction - drug effects
Pancuronium - antagonists & inhibitors
Recurrence
Time Factors
Tubocurarine - antagonists & inhibitors
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Summary:The possibility of “recurarization” after antagonism of the competitive neuromuscular block with anticholinesterases was studied. Observations were made on the time-course of the block in five patients at risk from recurarization because of multiple organ failure and who demonstrated unusually prolonged blockade. In none of these patients did the block recur. We conclude that, provided spontaneous recovery of neuromuscular transmission has made progress before the antagonism, and that the patient does not deteriorate or become exhausted afterwards, recurarization is unlikely.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/49.5.485