Role of Prostaglandins in the Control of Renin Secretion in the Dog

• Published in: Circulation research 1977-05, Vol.40 (5), p.459-464
• Main Authors: YUN, JOHN, KELLY, GERALD, BARTTER, FREDERIC C, SMITH, HAROLD
• Format: Article
• Language: English
• Subjects: Animals; Blood Pressure - drug effects; Dogs; Female; Glomerular Filtration Rate - drug effects; Heart Rate - drug effects; Indomethacin - pharmacology; Kidney - blood supply; Kidney - physiology; Potassium - metabolism; Prostaglandins E - physiology; Prostaglandins F - physiology; Regional Blood Flow - drug effects; Renin - metabolism; Sodium - metabolism; Urine
• ISSN: 0009-7330; 1524-4571
• DOI: 10.1161/01.RES.40.5.459

Infusion of indomethacin into anesthetized, saltdepleted dogs caused an increase in mean arterial blood pressure (MABP), and decreases in heart rate (HR), urine flow rate (V), renal plasma flow (RPF), and renin secretion rate. MABP was 112.1 ± 5.4 mm Hg during control periods and was 147.7 ± 5.6 mm Hg (P < 0.005) 80 minutes after the infusion of indomethacin. V was 0.38 ± 0.06 ml/min during control periods and was 0.08 ± 0.01 ml/min (P < 0.005) 80 minutes after the infusion of indomethacin. RPF was 126.3 ± 13.3 ml/min and 41.5 ± 7.5 ml/ min, respectively (P < 0.005), before and after 80 minutes of infusion. Renin secretion rate decreased from 1,194.1 ± 353.9 U/min during control periods to reach 384.0 ± 125.8 U/min (P < 0.025) by 80 minutes of infusion of indomethacin. Subsequent infusion of prostaglandin E2 (PGE2) into the renal artery for 80 minutes caused increases of V to 0.53 ± 0.13 ml/min (P < 0.01), of RPF to 102.4 ± 23.1 ml/min (P < 0.01), and of rennin secretion rate to 2,582.6 ± 786.4 U/min (P < 0.005). The decrease in renin secretion rate during the infusion of indomethacin persisted when renal perfusion pressure (RPP) was maintained relatively constant before and during the infusion of indomethacin. Furthermore, we found that infusion of prostaglandin E1 (PGE1) into the kidney gave the same pattern of response as PGE2. The data suggest that PGE1 and PGE2 play a role in the control of renin secretion.