Determination of Clonazepam in Tablets by dc Polarography

A simple and convenient method for the routine determination of clonazepam in tablets by dc polarography is described. Clonazepam is extracted from the sample by ethanol and diluted with pH 4.15 acetate buffer in a volumetric flask. The filtered solution is then polarographed at the dropping mercury...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1978-05, Vol.67 (5), p.731-733
Main Authors: Vinh, C.T., Braun, J., Plourde, J.R.
Format: Article
Language:English
Subjects:
Anticonvulsants-clonazepam
Anticonvulsants—clonazepam dc polarographic analysis in tablets
Benzodiazepinones - analysis
Clonazepam - analysis
clonazepam in tablets
Clonazepam-dc polarographic analysis in tablets
dc polarographic analysis in tablets
dc Polarography-analysis
dc Polarography—analysis clonazepam in tablets
Polarography - methods
Tablets - analysis
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Description
Summary:A simple and convenient method for the routine determination of clonazepam in tablets by dc polarography is described. Clonazepam is extracted from the sample by ethanol and diluted with pH 4.15 acetate buffer in a volumetric flask. The filtered solution is then polarographed at the dropping mercury electrode versus the saturated calomel electrode. The polarographic wave is well developed; the determination is quantitative, precise, and accurate.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600670551