Interaction of Some Pharmaceuticals with Macromolecules II: Binding of Certain Benzoic Acid Derivatives by Polysorbate 80 and Cetomacrogol 1000

The magnitude of intermolecular association occurring in aqueous solution between benzoic acid, a series of amino-, chloro-, and hydroxybenzoic acids, and two macromolecules, polysorbate 80 and cetomacrogol 1000, was determined by means of an equilibrium dialysis technique. All the benzoic acids stu...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1965-10, Vol.54 (10), p.1495-1499
Main Authors: Patel, Nagin K., Foss, Noel E.
Format: Article
Language:English
Subjects:
Aminobenzoates
Benzoates
Chemical Phenomena
Chemistry
Dialysis
Hydrogen-Ion Concentration
Macromolecular Substances
Surface-Active Agents
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Summary:The magnitude of intermolecular association occurring in aqueous solution between benzoic acid, a series of amino-, chloro-, and hydroxybenzoic acids, and two macromolecules, polysorbate 80 and cetomacrogol 1000, was determined by means of an equilibrium dialysis technique. All the benzoic acids studied were found to exhibit reversible association with the surfactants of the polyether type. The degree of interaction between the aromatic acids and the macromolecules appears to be dependent upon the type of functional group and its position in the interacting molecule. The binding affinity of polysorbate 80 for benzoic acid decreased with an increase in pH. The binding of the benzoic acids by polysorbate 80 and cetomacrogel 1000 was found to be describable by a Freundlich-type adsorption relationship.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600541020