Recycling with nicotine patches in smoking cessation

The aim was to evaluate if recycling of failures from a smoking cessation study may be of value. The study comprised 126 smokers (50%) of 252 failures, from a double‐blind smoking cessation trial with nicotine patch, who accepted recycling after 1 year. Subjects were allocated nicotine patches deliv...

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Bibliographic Details
Published in:Addiction (Abingdon, England) England), 1993-04, Vol.88 (4), p.533-539
Main Authors: TØNNESEN, PHILIP, NØRREGAARD, JESPER, SÄWE, URBAIN, SIMONSEN, KÅRE
Format: Article
Language:English
Subjects:
Addictive behaviors
Administration, Cutaneous
Adult
Adult and adolescent clinical studies
Aged
Biological and medical sciences
Cessation
Cotinine - pharmacokinetics
Dose-Response Relationship, Drug
Female
Follow-Up Studies
Humans
Male
Medical sciences
Middle Aged
Nicotine - administration & dosage
Nicotine - adverse effects
Nicotine patches
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Recurrence
Relapse
Saliva - metabolism
Smoking
Smoking Cessation
Substance Withdrawal Syndrome - etiology
Treatment
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Summary:The aim was to evaluate if recycling of failures from a smoking cessation study may be of value. The study comprised 126 smokers (50%) of 252 failures, from a double‐blind smoking cessation trial with nicotine patch, who accepted recycling after 1 year. Subjects were allocated nicotine patches delivering 15, 20 or 25 mg of nicotine (over 16 hours) according to their base‐line saliva cotinine concentrations in an open trial. The treatment period was 12 weeks followed by tapering over 6 weeks. The percentage of quitters after 3, 12, 26, and 52 weeks was 44, 20, 7 and 6%, respectively. After 26 weeks, all subjects had relapsed in the group previously treated with active nicotine patch compared with 12% abstainers in the previous placebo subjects. The sustained abstinence rate without slips after one year was 2%. Recycling does not seem to be of long‐term clinical relevance in our set‐up for subjects initially treated with nicotine, but of some value in subjects quitting without nicotine therapy initially.
ISSN:0965-2140
1360-0443
DOI:10.1111/j.1360-0443.1993.tb02060.x