Cold Agglutinins in Infectious Mononucleosis and Heterophil-Antibody-negative Mononucleosis-like Syndromes

Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil-positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases)....

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Bibliographic Details
Published in:Blood 1977-08, Vol.50 (2), p.195-202
Main Authors: Horwitz, Charles A., Moulds, John, Henle, Werner, Henle, Gertrude, Polesky, Herbert, Balfour, Henry H., Schwartz, Burton, Hoff, Tom
Format: Article
Language:English
Subjects:
Agglutinins - analysis
Antibodies, Heterophile
Antibodies, Viral - analysis
Autoantibodies - analysis
Cold Temperature
Cytomegalovirus - isolation & purification
Herpesvirus 4, Human - isolation & purification
Humans
I Blood-Group System
Immunoglobulin G - analysis
Immunoglobulin M - analysis
Infectious Mononucleosis - immunology
Infectious Mononucleosis - microbiology
Papain
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Summary:Cold agglutinins (CA) were evaluated prospectively in patients with various mononucleosis syndromes and in a large control group. Cold agglutinins with anti-i specificity were seen mainly in heterophil-positive or -negative Epstein-Barr virus (EBV)-induced infectious mononucleosis (31.8% of cases). Unclassified CA with equal reactivity against cord and adult erythrocytes were seen in 56 of 150 (37.3%) cases of heterophil-antibody-positive infectious mononucleosis (IM), in 1 of 7 (14.3%) cases of heterophil-negative EBV-induced IM, and in 12 of 31 (38.7%) cases of the heterophil-negative mononucleosis-like syndrome due to cytomegalovirus or other unspecified agents. One patient with heterophil-positive IM had a persistent, partially papain sensitive CA with anti-Pr-like activity. Anti-i CA were seen in < 1.0% of healthy young adults (500) or patients without mononucleosis (500) submitted for heterophil studies. Unclassified CA were noted in 3.2% of the latter 1000 samples.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V50.2.195.195