Herpesvirus saimiri-induced lymphoproliferative disease in howler monkeys

Four of 5 howler monkeys (Alouatta caraya) experimentally infected with Herpesvirus saimiri (HVS) developed a rapidly fatal malignant lymphoma accompanied by peripheral T-cell lymphocytosis. HVS was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived f...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1977-07, Vol.59 (1), p.165-171
Main Authors: Rangan, S R, Martin, L N, Enright, F M, Abee, C R
Format: Article
Language:English
Subjects:
Alouatta
Animals
Antigens, Viral
Cell Membrane - immunology
Cells, Cultured
Erythrocytes - immunology
Haplorhini
Herpesviridae - isolation & purification
Herpesvirus 2, Saimiriine - immunology
Herpesvirus 2, Saimiriine - isolation & purification
Immunity
Immunosuppression
Lymphocyte Activation
Lymphoma - etiology
Lymphoma - immunology
Lymphoma - microbiology
Lymphoma - pathology
Mitogens - pharmacology
Neoplasms, Experimental - etiology
Neoplasms, Experimental - immunology
Neoplasms, Experimental - microbiology
Neoplasms, Experimental - pathology
Species Specificity
T-Lymphocytes - microbiology
Tumor Virus Infections - immunology
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Summary:Four of 5 howler monkeys (Alouatta caraya) experimentally infected with Herpesvirus saimiri (HVS) developed a rapidly fatal malignant lymphoma accompanied by peripheral T-cell lymphocytosis. HVS was isolated from fresh and tissue cultured blood and tissue lymphocytes and from cell cultures derived from nonlymphoid organs. Humoral antibodies against HVS-induced antigens were detected in the sera of the animals. The in vitro response of the peripheral blood lymphocytes to mitogenic stimulants was depressed following HVS infection.
ISSN:0027-8874