N-terminal probrain natriuretic peptide predicts 1-year mortality following acute stroke: possible evidence of occult cardiac dysfunction among patients with acute stroke

Brain natriuretic peptide (BNP) is a vasoactive peptide hormone synthesized in the cardiac atrium and ventricular myocardium. Increased levels of BNP are associated with various cardiovascular insults. In response to fluid overload, BNP is cleaved from its precursor proBNP resulting in the release o...

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Bibliographic Details
Published in:Age and ageing 2010-11, Vol.39 (6), p.752-755
Main Authors: Idris, Iskandar, Hill, Robert, Ross, Ian, Sharma, Jagdish C.
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Aged
Aged, 80 and over
Atrial Natriuretic Factor - blood
Biochemical markers
Cardiovascular disease
Disease management
Dysfunction
Female
Heart Diseases - blood
Heart Diseases - mortality
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Occult
Peptides
Pilot Projects
Predictive Value of Tests
Protein Precursors - blood
Risk Factors
Stroke
Stroke - blood
Stroke - mortality
Strokes
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Summary:Brain natriuretic peptide (BNP) is a vasoactive peptide hormone synthesized in the cardiac atrium and ventricular myocardium. Increased levels of BNP are associated with various cardiovascular insults. In response to fluid overload, BNP is cleaved from its precursor proBNP resulting in the release of N-terminal (NT)-proBNP. NT-proBNP is an established diagnostic marker of sub-clinical heart failure and predicts cardiovascular events and mortality among asymptomatic patients as well as in patients with coronary artery disease independent of conventional cardiovascular risk factors. Here, a study investigating the role of NT-proBNP in predicting 1-year mortality of acute stroke in relation to various cardiovascular and biochemical parameters, is presented.
ISSN:0002-0729
1468-2834
DOI:10.1093/ageing/afq098