The effect of ultra violet B (TL-01) phototherapy on epidermal expression of p53 protein in psoriatic plaques

Background: Psoriasis is a genetically determined inflammatory skin disease. It is now recognized that narrow band TL‐01 phototherapy is an effective treatment for psoriasis. However, ultraviolet (UV) exposure induces p53 mutations in keratinocytes and repeated exposure of skin to UV radiation resul...

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Published in:Photodermatology, photoimmunology & photomedicine photoimmunology & photomedicine, 2006-02, Vol.22 (1), p.12-17
Main Authors: Jasim, Z. F., Lioe, T. F., McKenna, K. E., Robson, T., Ouhtit, A.
Format: Article
Language:English
Subjects:
Adult
apoptosis
Biological and medical sciences
Biopsy
Dermatology
Female
Humans
Immunohistochemistry
Keratinocytes - cytology
Keratinocytes - radiation effects
Male
Medical sciences
Middle Aged
p53 expression
phototherapy
psoriasis
Psoriasis - pathology
Psoriasis - radiotherapy
Psoriasis. Parapsoriasis. Lichen
skin cancer
TL-01
Tumor Suppressor Protein p53 - metabolism
Tumor Suppressor Protein p53 - radiation effects
Tumors of the skin and soft tissue. Premalignant lesions
Ultraviolet Therapy - methods
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Summary:Background: Psoriasis is a genetically determined inflammatory skin disease. It is now recognized that narrow band TL‐01 phototherapy is an effective treatment for psoriasis. However, ultraviolet (UV) exposure induces p53 mutations in keratinocytes and repeated exposure of skin to UV radiation results in clonal expansion of these initiated p53‐mutant cells within the epidermis. Aim: The present study aims to examine epidermal p53 expression in the skin of psoriatic patients at different time points following TL‐01 phototherapy. Methods: Skin samples from patients suffering from plaque‐type psoriasis, collected before, during and at the final stages of TL‐01 phototherapy were examined for p53 expression by immunohistochemistry. Results/Conclusion: Our results showed an increase in p53 expressing keratinocytes following TL‐01 phototherapy. Some of these cells were arranged spatially, as conical clones arising from putative stem cell compartments, suggesting that the chronic TL‐01 treatment might have triggered cell growth and clonal expansion, an important step in initiating skin carcinogenesis.
ISSN:0905-4383
1600-0781
DOI:10.1111/j.1600-0781.2006.00197.x