Hydroxyproline-containing protein adsorbed on to cellular elements of whole human blood

CURRENT hypotheses suggest that blood clotting occurs when, as a primary event, platelets come into direct contact with collagenous fibrils which have been exposed in vessel walls. We report here that a collagen component is normally associated with the cellular elements of blood. It was demonstrate...

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Bibliographic Details
Published in:Nature (London) 1977-05, Vol.267 (5608), p.272-274
Main Authors: MILLER, ROBIN, ENGEL, M. B, CATCHPOLE, H. R
Format: Article
Language:English
Subjects:
Adsorption
Adult
Aged
Blood Cells - analysis
Blood Cells - metabolism
Blood Coagulation
Collagen - blood
Collagen - metabolism
Complement C1 - analysis
Female
Fluorescent Antibody Technique
Humanities and Social Sciences
Humans
Hydroxyproline - blood
letter
Male
Middle Aged
multidisciplinary
Protein Binding
Science
Science (multidisciplinary)
Citations: Items that this one cites
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Summary:CURRENT hypotheses suggest that blood clotting occurs when, as a primary event, platelets come into direct contact with collagenous fibrils which have been exposed in vessel walls. We report here that a collagen component is normally associated with the cellular elements of blood. It was demonstrated by analysing whole blood and its fractions for protein-bound hydroxyproline, and shown by immunofluorescence in clotted blood smears using a specific antiserum to human collagen. As a blood component it is distinct from and additional to C1q, the hydroxyproline-containing protein which is a part of the first component of complement.
ISSN:0028-0836
1476-4687
DOI:10.1038/267272a0