Toxoplasma gondii: A morphometric analysis of the wall and epithelial cells of pigs intestine

The aim of this study was to perform a morphometric analysis of the different layers of the jejunal wall and epithelial cells of pigs with toxoplasmosis. Experiments were conducted using 10, 88-day-old crossbred (Pietran × Wessex) pigs divided into two groups: control ( n = 5) and experimental ( n =...

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Bibliographic Details
Published in:Experimental parasitology 2010-08, Vol.125 (4), p.380-383
Main Authors: da Silva, Patrícia de Cássia, Shiraishi, Celina Sayuri, Silva, Aristeu Vieira da, Gonçalves, Gentil Ferreira, Sant’Ana, Débora de Mello Gonçales, Araújo, Eduardo José de Almeida
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Glycoconjugates
Histology
Intestinal Mucosa - parasitology
Intestinal Mucosa - pathology
Jejunum - parasitology
Jejunum - pathology
Life cycle. Host-agent relationship. Pathogenesis
Mammalia
Mice
Morphometry
Mucins
Protozoa
Small intestine
Sus scrofa
Sus scrofa - parasitology
Swine
Swine Diseases - parasitology
Swine Diseases - pathology
Toxoplasma gondii
Toxoplasmosis
Toxoplasmosis, Animal - parasitology
Toxoplasmosis, Animal - pathology
Vertebrates: general zoology, morphology, phylogeny, systematics, cytogenetics, geographical distribution
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Summary:The aim of this study was to perform a morphometric analysis of the different layers of the jejunal wall and epithelial cells of pigs with toxoplasmosis. Experiments were conducted using 10, 88-day-old crossbred (Pietran × Wessex) pigs divided into two groups: control ( n = 5) and experimental ( n = 5). The experimental group consisted of animals inoculated orally with 5000 sporulated oocysts of a genotype III strain of Toxoplasma gondii. At 30 and 60 days following inoculation, the animals were anaesthetised for jejunal biopsy. The intestinal segments were processed routinely for histology. Transverse cuts (4 μm thick) were stained with haematoxylin and eosin (HE), Periodic Acid Schiff (PAS), Alcian Blue (AB), pH 2.5, and Alcian Blue (AB), pH 1.0. We observed hypertrophy of the jejunal wall, increased enterocyte height, and a decreased number of intraepithelial lymphocytes in the infected animals. There were no changes in the number of goblet cells.
ISSN:0014-4894
1090-2449
DOI:10.1016/j.exppara.2010.03.004