Detection of anti-Candida antibodies by the indirect immunofluorescence assay in patients with cancer in the orofacial region

An indirect immunofluorescence assay was performed to detect antibodies to Candida albicans blastospores and germ tubes. Serum specimens were obtained from 82 patients with neoplastic diseases in the orofacial region and thrush of the oral mucosa. C. albicans was identified in the oral cavity of 63...

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Bibliographic Details
Published in:Folia microbiologica 2002-01, Vol.47 (6), p.732-736
Main Authors: DORKO, E, JENCA, A, PILIPCINEC, E, TKACIKOVA, L'
Format: Article
Language:English
Subjects:
Antibodies
Antibodies, Fungal - blood
Biological and medical sciences
Candida
Candida albicans - immunology
Candida albicans - isolation & purification
Candidiasis - complications
Candidiasis - immunology
Candidiasis - microbiology
Candidiasis, Oral - complications
Candidiasis, Oral - immunology
Candidiasis, Oral - microbiology
Carcinoma - blood
Carcinoma - complications
Carcinoma - microbiology
Ent and stomatologic mycoses
Female
Fluorescent Antibody Technique, Indirect
Germ tubes
Herpes viruses
Human mycoses
Humans
Immunofluorescence
Infectious diseases
Male
Medical sciences
Mouth Mucosa - microbiology
Mouth Neoplasms - blood
Mouth Neoplasms - complications
Mouth Neoplasms - microbiology
Mycoses
Oral cavity
Radiation therapy
Tubes
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Summary:An indirect immunofluorescence assay was performed to detect antibodies to Candida albicans blastospores and germ tubes. Serum specimens were obtained from 82 patients with neoplastic diseases in the orofacial region and thrush of the oral mucosa. C. albicans was identified in the oral cavity of 63 patients investigated but serum anti-Candida antibodies were detected in only 23 of them. Serological examination showed that titers of antibodies to C. albicans blastospores ranged from 1:20 to 1:1280. High titers from 1:640 to 1:1280 were detected in patients without antibiotic, cytostatic, or radiotherapeutic treatment. The titers of antibodies to C. albicans germ tubes ranged from 1:20 to 1:640. Our results indicate that titers of antibodies to the C. albicans germ tubes were lower and were detected in a smaller number of patients.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02818680