Strain-Controlled Release of Molecules from Arrayed Microcapsules Supported on an Elastomer Substrate

Performing under strain: Microcapsules arrayed on an elastomer substrate pumped out preloaded molecules upon mechanical stretching of the substrate as a result of a decrease in microcapsule volume. This technology could be applied to drug release, for example, from a flexible patch containing the dr...

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2011-01, Vol.50 (3), p.724-727
Main Authors: Hyun, Dong Choon, Moon, Geon Dae, Park, Choo Jin, Kim, Bong Soo, Xia, Younan, Jeong, Unyong
Format: Article
Language:English
Subjects:
Capsules - chemistry
Dimethylpolysiloxanes - chemistry
drug delivery
Elastomers - chemistry
Fluorescent Dyes - chemistry
Mechanical Phenomena
microarrays
microcapsules
Microscopy, Atomic Force
Rhodamines - chemistry
Staining and Labeling
strain response
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Summary:Performing under strain: Microcapsules arrayed on an elastomer substrate pumped out preloaded molecules upon mechanical stretching of the substrate as a result of a decrease in microcapsule volume. This technology could be applied to drug release, for example, from a flexible patch containing the drug through mechanical stimulation by opening and closing of the hand (see picture).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201004838