Tumor-initiating cells and tumor vascularization

Tumor‐initiating cells (TICs) with stem‐like cell properties initiate and sustain progressive growth, resulting in a heterogeneous tumor mass. The survival and growth of tumors rely on the development of a vasculature to provide nutrients and oxygen. Crosstalk between TICs and vascularization may be...

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Bibliographic Details
Published in:Pediatric blood & cancer 2011-03, Vol.56 (3), p.335-340
Main Authors: Zhang, Li-Zhi, Zhang, Chang-Qing, Yan, Zhen-Yu, Yang, Qing-Cheng, Jiang, Yao, Zeng, Bing-Fang
Format: Article
Language:English
Subjects:
Animals
cancer stem cells (CSCs)
dormancy
gene
Humans
hypoxia
metastasis
Neoplasms - blood supply
Neoplasms - pathology
Neoplastic Stem Cells - pathology
Neovascularization, Pathologic - pathology
tumor-initiating cells (TICs)
vascular niche
vascularity
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Summary:Tumor‐initiating cells (TICs) with stem‐like cell properties initiate and sustain progressive growth, resulting in a heterogeneous tumor mass. The survival and growth of tumors rely on the development of a vasculature to provide nutrients and oxygen. Crosstalk between TICs and vascularization may be one of the central players in the initiation, long‐term maintenance, and progression of tumors. This review surveys current evidence concerning the crosstalk that occurs in tumor/stromal interactions, including genetic change, vascular niche, hypoxia, and dormancy of tumors. A better understanding of this crosstalk might help provide the basis for developing more effective therapeutic drug targets. Pediatr Blood Cancer 2011;56:335–340. © 2010 Wiley‐Liss, Inc.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.22886