Endocardial Fibroelastosis of Large Mammals

Normal hearts of a mouse, rat, man, sea lion, hippopotamus, elephant, and blue whale were shown to have different numbers of myocardial fibers, 10 to 10, based on calculations involving their myocardial fiber diameters and nuclear density counts. These two parameters did not vary greatly in the diff...

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Bibliographic Details
Published in:Circulation research 1965-04, Vol.16 (4), p.383-390
Main Authors: Black-schaffer, B, Grinstead, Carl E, Braunstein, John N
Format: Article
Language:English
Subjects:
Adolescent
Animals
Artiodactyla
Biometry
Cardiomegaly
Carnivora
Cetacea
Elastic Tissue
Elasticity
Elephants
Endocardial Fibroelastosis
Endomyocardial Fibrosis
Heart
Histology, Comparative
Humans
Hypertrophy
Infant
Mammals
Mice
Myocardium
Old Medline
Pathology
Rats
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Summary:Normal hearts of a mouse, rat, man, sea lion, hippopotamus, elephant, and blue whale were shown to have different numbers of myocardial fibers, 10 to 10, based on calculations involving their myocardial fiber diameters and nuclear density counts. These two parameters did not vary greatly in the different species. However, their heart weights ranged from 10 to 10 g. The larger mammals have endocardial fibroelastosis of their hearts and very thick aortas. These anatomic findings were explained by employing principles of hydrostatics and proposing that elastic tissue is required to help withstand the high mural tension resulting from the long radii and the hydrostatic pressures in the heart chambers and aortic lumen.
ISSN:0009-7330
1524-4571
DOI:10.1161/01.RES.16.4.383