Serum glutamic oxalacetic transaminase/glutamic pyruvic transaminase ratios in hepatocellular carcinoma

• Published in: Cancer 1977-07, Vol.40 (1), p.319-324
• Main Authors: Shimokawa, Yutaka, Okuda, Kunio, Kubo, Yasuhiko, Kaneko, Akira, Arishima, Tsuneaki, Nagata, Eisuke, Hashimoto, Masaharu, Sawa, Yasuhiko, Nagasaki, Yoshikazu, Kojiro, Masamichi, Sakamoto, Kazuyoshi, Nakashima, Toshiro
• Format: Article
• Language: English
• Subjects: Alanine Transaminase - blood; Alkaline Phosphatase - blood; Aspartate Aminotransferases - blood; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - enzymology; Humans; L-Lactate Dehydrogenase - blood; Leucyl Aminopeptidase - blood; Liver Cirrhosis - blood; Liver Cirrhosis - enzymology; Liver Neoplasms - blood; Liver Neoplasms - enzymology; Neoplasm Metastasis
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/1097-0142(197707)40:1<319::AID-CNCR2820400145>3.0.CO;2-Q

Serum enzyme activities were studied in 131 cases of hepatocellular carcinoma (HCC), 76 cases of metastatic liver carcinomas (MLC) and 234 cases of hepatic cirrhosis. SGOT was elevated above SGPT in most of the time in these patients, SGOT/SGPT was greater in HCC compared with other groups, and that this ratio increased during the preterminal period more markedly in patients with HCC because of the significant increase of SGOT in the face of relatively stable SGPT. Preterminal rises of alkaline phosphatase and LDH activities were more pronounced in MLC. Leucine aminopeptidase activity exhibited no characteristic feature of diagnostic value. Of the five enzymes, SGOT changes were more closely correlated with the growth of HCC; SGPT reflected more of the liver parenchymal damage while SGOT was probably accounted for in part by tumor‐derived GOT. Other clinical and pathological implications are discussed. Cancer 40:319–324, 1977.