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Immune responses of chickens fed the androgen analog mibolerone

Mibolerone, an androgen analog (17β-hydroxy-7α,17-dimethylestr-4-en-3-one), induces a slow but progressive involution of the bursa of Fabricius when fed to chickens at μg levels during the first 7 weeks of life. Chickens receiving mibolerone remained immunologically competent, evidenced by: 1) their...

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Bibliographic Details
Published in:Avian diseases 1977-04, Vol.21 (2), p.264-279
Main Authors: Romero, C. H., Purchase, H. G., Frank, F., Burmester, B. R., Kakuk, T. J., Chang, T. S.
Format: Article
Language:English
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Summary:Mibolerone, an androgen analog (17β-hydroxy-7α,17-dimethylestr-4-en-3-one), induces a slow but progressive involution of the bursa of Fabricius when fed to chickens at μg levels during the first 7 weeks of life. Chickens receiving mibolerone remained immunologically competent, evidenced by: 1) their antibody response to nonreplicating antigens and infectious antigens; 2) the number of antibody-producing cells in their spleens; 3) the stimulation of their peripheral leukocytes with the plant mitogen phytohemagglutinin; and 4) their capacity to resist challenge with Marek's disease virus and Newcastle disease virus after vaccinations with turkey herpes-virus and the B-1 LaSota strain. This, coupled with the fact that it prevents experimental lymphoid leukosis, makes mibolerone a potential agent to be used under field conditions for the control of lymphoid leukosis.
ISSN:0005-2086
1938-4351
DOI:10.2307/1589346