Electron Microscopy of the Red Cells in Erythropoietic Porphyria

With the aid of electron microscopy two different red cell lines have been identified in erythropoietic porphyria. A normal red cell series has been found in association with hemoglobin containing normoblastic nuclei and ferritin laden reticulocytes. The abnormal line presumably represents the porph...

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Bibliographic Details
Published in:Blood 1965-01, Vol.25 (1), p.49-55
Main Authors: Gross, Samuel, Schoenberg, Melvin D, Mumaw, Virgil
Format: Article
Language:English
Subjects:
Cell Nucleus
Cytoplasm
Electrons
Erythrocytes
Ferritins
Hemoglobins
Microscopy
Microscopy, Electron
Mitochondria
Old Medline
Porphyria, Erythropoietic
Porphyrias
Reticulocytes
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Summary:With the aid of electron microscopy two different red cell lines have been identified in erythropoietic porphyria. A normal red cell series has been found in association with hemoglobin containing normoblastic nuclei and ferritin laden reticulocytes. The abnormal line presumably represents the porphyrin containing cells. A possible explanation to account for the abnormality in heme synthesis has been proposed.
ISSN:0006-4971
1528-0020
DOI:10.1182/blood.V25.1.49.49