Hepatic Binding Protein: The Protective Role of Its Sialic Acid Residues

Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylati...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-08, Vol.197 (4304), p.667-668
Main Authors: Stockert, Richard J., Morell, Anatol G., Scheinberg, I. Herbert
Format: Article
Language:English
Subjects:
Acetylgalactosamine - metabolism
Amino acids
Asialoglycoproteins
Binding Sites
Blood plasma
Carrier proteins
Carrier Proteins - metabolism
Coal
Coumaric acids
Glycoproteins
Glycoproteins - metabolism
Liver - metabolism
Membrane Proteins - metabolism
Mucins - metabolism
Orosomucoid - metabolism
Pyrites
Sialic Acids - metabolism
Structure-Activity Relationship
Sulfur
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Description
Summary:Removal of sialic acid from a specific hepatic binding protein virtually abolishes its capacity to bind certain asialoglycoproteins. The loss of this capacity is the result of competition for the binding sites by galactosyl residues, of hepatic binding protein, that become terminal after desialylation.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.877581