Analysis of Hypotensive Mechanisms of Pindolol, a β-Adrenoceptor Blocking Drugs in Rats

The hypotensive mechanisms of pindolol in anesthetized and conscious rats were investigated. Pindolol caused a fall in blood pressure in anesthetized, conscious and spinal rats, though in conscious rats a higher dose of the drug was required to produce such a response. This hypotension with pindolol...

Full description

Saved in:
Bibliographic Details
Published in:Japanese journal of pharmacology 1977, Vol.27(2), pp.295-302
Main Authors: Ozawa, Hikaru, Matsubara, Toshiyuki, Chen, Chin-Song
Format: Article
Language:English
Subjects:
Adrenergic beta-Antagonists - pharmacology
Anesthesia, Intravenous
Animals
Antihypertensive Agents
Blood Pressure - drug effects
Consciousness
Dose-Response Relationship, Drug
Female
Guinea Pigs
Heart Rate - drug effects
In Vitro Techniques
Isoproterenol - pharmacology
Laminectomy
Male
Muscle Relaxation - drug effects
Pindolol - pharmacology
Rats
Sympathomimetics - pharmacology
Trachea - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The hypotensive mechanisms of pindolol in anesthetized and conscious rats were investigated. Pindolol caused a fall in blood pressure in anesthetized, conscious and spinal rats, though in conscious rats a higher dose of the drug was required to produce such a response. This hypotension with pindolol in anesthetized and conscious rats was markedly inhibited by pretreatment with the drug itself or other β-adrenoceptor blocking drugs. A similar phenomenon also occurred when isoproterenol was injected intravenously in anesthetized and conscious rats. The relationship between the hypotensive actions of four β-adrenoceptor blocking drugs in anesthetized rats and their intrinsic β-sympathomimetic actions in isolated catecholamine-depleted tracheal preparations was determined. Order of hypotensive potencies was the same as that of their intrinsic β-sympathomimetic action, namely, pindolol>carteolol>bufetolol≒propranolol (p
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.27.295