Endogenous opioid peptides: multiple agonists and receptors

Opioid peptides were assayed by inhibition of 3 H-naloxone and 3 H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact wit...

Full description

Saved in:
Bibliographic Details
Published in:Nature (London) 1977-06, Vol.267 (5611), p.495-499
Main Authors: Lord, John A. H, Waterfield, Angela A, Hughes, John, Kosterlitz, Hans W
Format: Article
Language:English
Subjects:
Animals
Benzomorphans - analogs & derivatives
Benzomorphans - metabolism
Brain - metabolism
Endorphins - metabolism
Enkephalins - metabolism
Guinea Pigs
Humanities and Social Sciences
Ileum - metabolism
Male
Mice
multidisciplinary
Naloxone - metabolism
Narcotic Antagonists - metabolism
Narcotics - metabolism
Oligopeptides - metabolism
Peptides - metabolism
Receptors, Opioid - metabolism
Science
Science (multidisciplinary)
Structure-Activity Relationship
Vas Deferens - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Opioid peptides were assayed by inhibition of 3 H-naloxone and 3 H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.
ISSN:0028-0836
1476-4687
DOI:10.1038/267495a0