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Endogenous opioid peptides: multiple agonists and receptors
Opioid peptides were assayed by inhibition of 3 H-naloxone and 3 H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact wit...
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| Published in: | Nature (London) 1977-06, Vol.267 (5611), p.495-499 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c334t-34084b27e213c6bb855cc09489baa89610b1909e9cd2a6a8ec4059d12525112a3 |
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| cites | cdi_FETCH-LOGICAL-c334t-34084b27e213c6bb855cc09489baa89610b1909e9cd2a6a8ec4059d12525112a3 |
| container_end_page | 499 |
| container_issue | 5611 |
| container_start_page | 495 |
| container_title | Nature (London) |
| container_volume | 267 |
| creator | Lord, John A. H Waterfield, Angela A Hughes, John Kosterlitz, Hans W |
| description | Opioid peptides were assayed by inhibition of
3
H-naloxone and
3
H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor. |
| doi_str_mv | 10.1038/267495a0 |
| format | article |
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3
H-naloxone and
3
H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/267495a0</identifier><identifier>PMID: 195217</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Animals ; Benzomorphans - analogs & derivatives ; Benzomorphans - metabolism ; Brain - metabolism ; Endorphins - metabolism ; Enkephalins - metabolism ; Guinea Pigs ; Humanities and Social Sciences ; Ileum - metabolism ; Male ; Mice ; multidisciplinary ; Naloxone - metabolism ; Narcotic Antagonists - metabolism ; Narcotics - metabolism ; Oligopeptides - metabolism ; Peptides - metabolism ; Receptors, Opioid - metabolism ; Science ; Science (multidisciplinary) ; Structure-Activity Relationship ; Vas Deferens - metabolism</subject><ispartof>Nature (London), 1977-06, Vol.267 (5611), p.495-499</ispartof><rights>Springer Nature Limited 1977</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-34084b27e213c6bb855cc09489baa89610b1909e9cd2a6a8ec4059d12525112a3</citedby><cites>FETCH-LOGICAL-c334t-34084b27e213c6bb855cc09489baa89610b1909e9cd2a6a8ec4059d12525112a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/195217$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lord, John A. H</creatorcontrib><creatorcontrib>Waterfield, Angela A</creatorcontrib><creatorcontrib>Hughes, John</creatorcontrib><creatorcontrib>Kosterlitz, Hans W</creatorcontrib><title>Endogenous opioid peptides: multiple agonists and receptors</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Opioid peptides were assayed by inhibition of
3
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3
H-naloxone and
3
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| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1977-06, Vol.267 (5611), p.495-499 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_84003234 |
| source | Nature |
| subjects | Animals Benzomorphans - analogs & derivatives Benzomorphans - metabolism Brain - metabolism Endorphins - metabolism Enkephalins - metabolism Guinea Pigs Humanities and Social Sciences Ileum - metabolism Male Mice multidisciplinary Naloxone - metabolism Narcotic Antagonists - metabolism Narcotics - metabolism Oligopeptides - metabolism Peptides - metabolism Receptors, Opioid - metabolism Science Science (multidisciplinary) Structure-Activity Relationship Vas Deferens - metabolism |
| title | Endogenous opioid peptides: multiple agonists and receptors |
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