Antigenic Relationship of Toxoplasma gondii and Besnoitia jellisoni

Morphologically Besnoitia and Toxoplasma resemble each other. Immunologically they are different but appear to have certain antigens in common. Rabbits were infected with Toxoplasma gondii and Besnoitia jellisoni both of which had been passed through chick embryo. Dye tests and hemagglutination test...

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Bibliographic Details
Published in:The Journal of parasitology 1965-04, Vol.51 (2), p.273-276
Main Authors: Lunde, Milford N., Jacobs, Leon
Format: Article
Language:English
Subjects:
Animals
Antibodies
Antigens
Apicomplexa
Ascitic Fluid
Complement Fixation Tests
Cross reaction
Dyes
Embryos
Hemagglutination
Hemagglutination Tests
Immunodiffusion
Infections
Mice
Old Medline
Parasitemia
Parasites
Precipitin Tests
Precipitins
Rabbits
Toxoplasma
Toxoplasmosis
Toxoplasmosis, Animal
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Summary:Morphologically Besnoitia and Toxoplasma resemble each other. Immunologically they are different but appear to have certain antigens in common. Rabbits were infected with Toxoplasma gondii and Besnoitia jellisoni both of which had been passed through chick embryo. Dye tests and hemagglutination tests were done using both Toxoplasma and Besnoitia as antigens. The organisms for the dye test and for preparation of HA antigens were derived from peritoneal exudates of intraperitoneally infected mice. The dye test was specific for both organisms with no titer demonstrated in the heterologous system. On the other hand, cross-reactions were demonstrated between Toxoplasma and Besnoitia in the hemagglutination test. The homologous titer was always higher than the heterologous titer. Complement-fixation test using only the Toxoplasma antigen showed a cross-reaction with Besnoitia antisera from these rabbits. Agargel diffusion on micro slides revealed precipitin lines in common with both systems. Rabbits infected with Besnoitia showed no immunity when challenged with a virulent strain of Toxoplasma and succumbed as rapidly as controls not previously infected. On the other hand, rabbits surviving infection with an avirulent Toxoplasma strain were immune to challenge with virulent Toxoplasma.
ISSN:0022-3395
1937-2345
DOI:10.2307/3276098