Rous Sarcomas in Chickens: Enhanced Growth Coexisting with Concomitant Immunity

Chickens bearing Rous sarcoma virus-induced tumors in one wing did not develop new tumors when subsequently inoculated with Rous sarcoma virus in the other wing. However, the second inoculation of Rous sarcoma virus caused accelerated growth of the established tumors. This phenomenon was found to be...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1977-09, Vol.197 (4308), p.1079-1082
Main Authors: McBride, Raymond A., Watanabe, Daniel H., Schierman, Louis W.
Format: Article
Language:English
Subjects:
Animal wings
Animals
Antigens, Neoplasm - administration & dosage
Antigens, Viral - administration & dosage
Avian Sarcoma Viruses - immunology
Bursa of Fabricius - immunology
Chickens
Embryos
Graft Rejection
Herpes zoster
Immunity
Inoculation
Neoplasm Transplantation
Ova
Ovaries
Sarcoma
Sarcoma, Avian - immunology
Sarcoma, Avian - pathology
Transplantation, Isogeneic
Tumors
Viruses
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Summary:Chickens bearing Rous sarcoma virus-induced tumors in one wing did not develop new tumors when subsequently inoculated with Rous sarcoma virus in the other wing. However, the second inoculation of Rous sarcoma virus caused accelerated growth of the established tumors. This phenomenon was found to be bursa-dependent. Paradoxically, established tumors in bursectomized chickens grew at a diminished rate if the chickens were reinoculated with Rous sarcoma virus.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.196336