Hydrogen-Bonded Dimers of Adenine and Uracil Derivatives

In concentrated solutions of either 9-ethyladenine or 1-cyclohexyluracil in deuterochloroform, absorption bands in the infrared spectrum demonstrate hydrogen bonding of the adenine and uracil derivatives with themselves. In dilute solutions, there is very little hydrogen bonding. However, when dilut...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1965-06, Vol.148 (3678), p.1734-1737
Main Authors: Hamlin, Roy M., Lord, R. C., Rich, Alexander
Format: Article
Language:English
Subjects:
Adenine
Albumins
Chemical Phenomena
Chemistry
Dimers
Hormones
Hydrogen
Hydrogen Bonding
Hydrogen bonds
Infrared spectrum
Molecules
Old Medline
Polymers
Purines
Solvents
Spectrum Analysis
Tumors
Uracil
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Summary:In concentrated solutions of either 9-ethyladenine or 1-cyclohexyluracil in deuterochloroform, absorption bands in the infrared spectrum demonstrate hydrogen bonding of the adenine and uracil derivatives with themselves. In dilute solutions, there is very little hydrogen bonding. However, when dilute solutions of 9-ethyladenine and 1-cyclohexyluracil are mixed, a series of bands appear which show that these molecules are hydrogen-bonding with each other much more strongly than with themselves. A study of the stoichiometry of this association indicates formation of 1:1 hydrogen-bonded pairs in solution.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.148.3678.1734