Metabolism and tissue distribution of (1,4,5,8-14C)--1,2-dichloronaphthalene in rats

The metabolism, absorption, distribution, and excretion of 1,2-dichloronaphthalene (DCN), a major component of halowax 1031 and 1000, are determined in rats. Dcn rapidly absorbs in the gastrointestinal tract and metabolizes to dihydrodiol. Unchanged, 42% of the dcn is excreted via feces, while 35% a...

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Bibliographic Details
Published in:Bulletin of environmental contamination and toxicology 1977-08, Vol.18 (2), p.177-183
Main Authors: Chu, I, Secours, V, Villeneuve, D C, Viau, A
Format: Article
Language:English
Subjects:
Animals
Bile - metabolism
Feces - analysis
Hydrocarbons, Chlorinated - chemical synthesis
Hydrocarbons, Chlorinated - metabolism
Hydrocarbons, Chlorinated - urine
Hydrolysis
Intestinal Absorption
Male
Naphthalenes - chemical synthesis
Naphthalenes - metabolism
Naphthalenes - urine
Organ Specificity
Rats
Time Factors
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Summary:The metabolism, absorption, distribution, and excretion of 1,2-dichloronaphthalene (DCN), a major component of halowax 1031 and 1000, are determined in rats. Dcn rapidly absorbs in the gastrointestinal tract and metabolizes to dihydrodiol. Unchanged, 42% of the dcn is excreted via feces, while 35% appears in urine as the glucuronide of a dihydrodiol.
ISSN:0007-4861
1432-0800
DOI:10.1007/BF01686064