The Effect of Small Doses of Chemically Pure Secretin on the Volume and Bicarbonate Output of the Pancreatic Juice in Dogs

Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of c...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1965-05, Vol.64 (1-2), p.106-108
Main Authors: SÄTERI, H., THULIN, L., WELANDER, B.
Format: Article
Language:English
Subjects:
Animals
Bicarbonates
Dogs
Old Medline
Pancreatic Juice
Pharmacology
Secretin
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Summary:Säteri, H., L. Thulin and B. Welander. The effect of small doses of chemically pure secretin on the volume and bicarbonate output of the pancreatic juice in dogs. Acta physiol. scand. 1965. 64. 106–108. The volume and bicarbonate output of the pancreatic juice during fasting and during infusion of chemically pure secretin at doses without effect on the liver were studied by a non‐surgical method. Eight experiments were made in 2 unanesthetized dogs. The doses ranged from 0.25 to 1.5 clinical units per kg b. w. and hr. At the smaller doses there was only a slight increase of the volume and the bicarbonate output. At the larger doses the maximum volume, 25 ml per 30 min, was about 3 times the initial and the maximum bicarbonate output, 1.4–2.7 meq per 30 min, about 50 times the initial in one dog and about 10 times in the other.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1965.tb04158.x